How CSI leveraged its vendor and warehouse networks to supply aflibercept for a leading CRO’s study within a tight deadline Challenge CSI was tasked by one of its CRO partners with sourcing 400 packs of aflibercept from the open market within a tight deadline of two-to-three weeks. A strict expiry date for the product was specified by the client, and the challenge was greater than usual as the order was placed during the Christmas period, which meant warehouse closures and delayed response times from suppliers. To make matters more complex, the client requested a change in quantities after the initial order, resulting in split deliveries that risked further extending the timescale. Solution Despite these obstacles, CSI successfully leveraged its relationship with a local vendor to secure the required quantity of the specified cancer medication. Effective communication and coordination between CSI, the client, the vendor and CSI’s warehouse were key during the disrupted holiday period and ensured smooth delivery and completion of quality control checks. Result The required quantity of aflibercept was successfully delivered to CSI’s warehouse for immediate distribution to hospitals. True to our promise that no patient would be turned away for lack of medication, the ophthalmology product was delivered within the specified timeframe to several hospitals in the United States.

Which trends will shape clinical trial supplies in 2025? The clinical trial supply industry is rapidly evolving, driven by the complexity of global studies and patient-centric approaches. As we enter 2025, key trends are set to reshape clinical supply solutions. CSI predicts that these changes will further emphasize the need for expert partners who can streamline operations and enhance trial outcomes. 1. Decentralized Clinical Trials (DCTs) Direct-to-patient (DTP) deliveries will become the norm. CSI can support sponsors by offering robust logistics frameworks, advanced tracking systems and expertise in managing temperature-sensitive shipments, ensuring compliance, efficiency and patient convenience. 2. Artificial Intelligence (AI) AI will optimize demand forecasting and inventory management, reducing waste and lowering costs. CSI’s AI-integrated tools streamline supply chains and will increase trial efficiency for our clients and predicts that these technologies will become indispensable in reducing trial delays and costs. 3. Localized Supply Networks With clinical trials expanding globally, localized supply hubs in Asia, Africa, and South America will become essential. CSI’s established global presence and expertise in navigating diverse regulations ensure seamless quality and compliance across regions. CSI serves as a reliable partner in building and maintaining these vital networks. 4. Sustainability Eco-friendly practices, such as biodegradable packaging and energy-efficient transport will become standard. CSI is committed to sustainable solutions, as an EcoVadis Platinum certified company, reducing the environmental impact of clinical supply chains. CSI predicts that sustainability will remain a top priority for the industry as companies align with global environmental goals. 5. Personalized Medicine Growth in personalized treatments, like cell and gene therapies, will demand flexible, patient-specific supply solutions and stringent cold chain management. CSI specializes in handling complex logistics for personalized medicine, ensuring timely and secure delivery. CSI predicts that this trend will drive demand for precisely tailored supply chain solutions. 6. Advanced Analytics Real-time and predictive analytics will enhance supply chain performance, mitigate risks and keep trials on schedule by identifying bottlenecks. Based on CSI’s experience utilizing advanced analytics tool TraceLink, these will play a pivotal role in future clinical supply strategies and avoiding supply delays. 7. Collaboration and Outsourcing Strong partnerships and outsourcing to specialised providers will be crucial for navigating complex trials, particularly those involving biologics, cancer therapies and rare diseases. CSI’s proven expertise in global studies and tailored clinical supply solutions make it a trusted partner for Biotech, Pharmaceutical and CRO companies. Conclusion The clinical trial supply industry in 2025 will be defined by adaptability, sustainability, and technological advancement; CSI predicts that sponsors will increasingly rely on expert partners to navigate these challenges. Based on CSI's experience and market knowledge, we are uniquely positioned to support our pharmaceutical and biotech clients with innovative tools and tailored solutions. CSI’s global reach ensures seamless operations, while its commitment to sustainability and advanced analytics drives efficiency. By embracing these trends, CSI serves as a trusted partner in accelerating drug development, ensuring more efficient trials, and delivering better outcomes for patients worldwide.

CSI’s seamless comparator export to China Export of expensive comparators from Europe to China with first leg documents and streamlined approach Read more - - Learn More Rapid Eylea Study Supply How CSI leveraged its vendor and warehouse networks to supply aflibercept for a leading CRO’s study within a tight deadline Read more Sourcing Flu Vaccines for a Global Trial How CSI’s regulatory guidance and robust sourcing solutions ensured the success of a global flu vaccine trial that could not afford to run behind schedule Read more Overcoming Drug Shortages How CSI leveraged relationships with multiple manufacturers to urgently supply large quantities of a generic drug to a global Phase 3 trial Read more - - Learn More Streamlining Biotechnology Supply Chains How CSI’s scientific insight delivered an agile sourcing model and substantial cost savings for a listed biotechnology company’s global trial Read more Oncology Product Batch Hunting How CSI delivered mission impossible: sourcing specific tested batches of an expensive oncology product from several European markets Read more Delivering Comparators for a Global Allergy Study How CSI used its scientific expertise at the protocol stage to provide flexibility in sourcing strategy and ensure high volumes of a single product were supplied on time to multiple countries Read more - - Learn More A Quality Solution to Clinical Trial Supply How the flexibility and initiative of CSI’s Quality team overcame challenges to ensure timely product supply for a partner’s ongoing clinical trial Read more - - Learn More Global Biotech Oncology Partnership How CSI supplied large quantities of ruxolitinib to a CRO’s ongoing Phase 3 oncology study involving 14 countries, nine depots and 67 site shipments Read more - - Learn More Delivering €1 million Savings for Pembrolizumab How CSI has saved a leading global pharmaceutical company €1 million by sourcing pembrolizumab from the market at the best possible price Read more Rescuing a Global Biotech's Oncology Study with Cetuximab How CSI rescued an oncology trial when a competitor failed to deliver, despite an extremely tight deadline and scarce supply on the market Read more Global Device Distribution CSI’s flexible approach to global distribution ensured a large CRO's five-year and three-year studies across a total of 18 countries could proceed without delay Read more - - Learn More Accelerating global AML study: How CSI streamlined Venetoclax and Azacitidine supply across 17 countries in record time CSI Efficiently Delivered Venetoclax and Azacitidine Across 17 Countries Read more - - Learn More Case Studies CSI’s deep understanding of drug development means we can provide innovative solutions to supply global clinical trials, however complex. Learn how we do this below Our partners work tirelessly to improve patient outcomes and quality of life. At CSI we accelerate drug development by designing and delivering highly efficient and robust supply chains that allow our partners to deliver their clinical trials on time and budget.

More case studies CSI Efficiently Delivered Venetoclax and Azacitidine Across 17 Countries Read all Accelerating global AML study: How CSI streamlined Venetoclax and Azacitidine supply across 17 countries in record time Export of expensive comparators from Europe to China with first leg documents and streamlined approach Read all CSI’s seamless comparator export to China CSI’s flexible approach to global distribution ensured a large CRO's five-year and three-year studies across a total of 18 countries could proceed without delay Read all Global Device Distribution How CSI rescued an oncology trial when a competitor failed to deliver, despite an extremely tight deadline and scarce supply on the market Read all Rescuing a Global Biotech's Oncology Study with Cetuximab How CSI has saved a leading global pharmaceutical company €1 million by sourcing pembrolizumab from the market at the best possible price Read all Delivering €1 million Savings for Pembrolizumab How CSI supplied large quantities of ruxolitinib to a CRO’s ongoing Phase 3 oncology study involving 14 countries, nine depots and 67 site shipments Read all Global Biotech Oncology Partnership How the flexibility and initiative of CSI’s Quality team overcame challenges to ensure timely product supply for a partner’s ongoing clinical trial Read all A Quality Solution to Clinical Trial Supply How CSI delivered mission impossible: sourcing specific tested batches of an expensive oncology product from several European markets Read all Oncology Product Batch Hunting How CSI used its scientific expertise at the protocol stage to provide flexibility in sourcing strategy and ensure high volumes of a single product were supplied on time to multiple countries Read all Delivering Comparators for a Global Allergy Study How CSI’s regulatory guidance and robust sourcing solutions ensured the success of a global flu vaccine trial that could not afford to run behind schedule Read all Sourcing Flu Vaccines for a Global Trial How CSI’s scientific insight delivered an agile sourcing model and substantial cost savings for a listed biotechnology company’s global trial Read all Streamlining Biotechnology Supply Chains How CSI leveraged relationships with multiple manufacturers to urgently supply large quantities of a generic drug to a global Phase 3 trial Read all Overcoming Drug Shortages Challenge CSI was tasked by one of its CRO partners with sourcing 400 packs of aflibercept from the open market within a tight deadline of two-to-three weeks. A strict expiry date for the product was specified by the client, and the challenge was greater than usual as the order was placed during the Christmas period, which meant warehouse closures and delayed response times from suppliers. To make matters more complex, the client requested a change in quantities after the initial order, resulting in split deliveries that risked further extending the timescale. Solution Despite these obstacles, CSI successfully leveraged its relationship with a local vendor to secure the required quantity of the specified ophthalmology medication. Effective communication and coordination between CSI, the client, the vendor and CSI’s warehouse were key during the disrupted holiday period and ensured smooth delivery and completion of quality control checks. Result The required quantity of aflibercept was successfully delivered to CSI’s warehouse for immediate distribution to hospitals. True to our promise that no patient would be turned away for lack of medication, the ophthalmology product was delivered within the specified timeframe to several hospitals in the United States. Case Study Rapid Eylea Study Supply How CSI leveraged its vendor and warehouse networks to supply aflibercept for a leading CRO’s study within a tight deadline Challenge To source 400 packs of aflibercept from the open market for a CRO’s trial – within a tight deadline and during a holiday period Solution Effective communication and coordination between CSI, the client, a local vendor and CSI’s warehouse ensured smooth delivery Result The required quantity of medication was successfully delivered to CSI’s warehouse for immediate distribution to hospitals Get in touch with a member of our experienced team today to discuss your clinical trial supply requirements Contact us Submit Company type

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