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More case studies

Export of expensive comparators from Europe to China with first leg documents and streamlined approach

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CSI’s seamless comparator export to China

CSI’s flexible approach to global distribution ensured a large CRO's five-year and three-year studies across a total of 18 countries could proceed without delay

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Global Device Distribution

How CSI rescued an oncology trial when a competitor failed to deliver, despite an extremely tight deadline and scarce supply on the market

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Rescuing a Global Biotech's Oncology Study with Cetuximab

How CSI supplied large quantities of ruxolitinib to a CRO’s ongoing Phase 3 oncology study involving 14 countries, nine depots and 67 site shipments

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Global Biotech Oncology Partnership

How the flexibility and initiative of CSI’s Quality team overcame challenges to ensure timely product supply for a partner’s ongoing clinical trial

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A Quality Solution to Clinical Trial Supply

How CSI delivered mission impossible: sourcing specific tested batches of an expensive oncology product from several European markets

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Oncology Product Batch Hunting

How CSI used its scientific expertise at the protocol stage to provide flexibility in sourcing strategy and ensure high volumes of a single product were supplied on time to multiple countries

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Delivering Comparators for a Global Allergy Study

How CSI’s regulatory guidance and robust sourcing solutions ensured the success of a global flu vaccine trial that could not afford to run behind schedule

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Sourcing Flu Vaccines for a Global Trial

How CSI leveraged its vendor and warehouse networks to supply aflibercept for a leading CRO’s oncology study within a tight deadline

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Rapid Oncology Study Supply

How CSI’s scientific insight delivered an agile sourcing model and substantial cost savings for a listed biotechnology company’s global trial

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Streamlining Biotechnology Supply Chains

How CSI leveraged relationships with multiple manufacturers to urgently supply large quantities of a generic drug to a global Phase 3 trial

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Overcoming Drug Shortages

Challenge

Pembrolizumab is a type of immunotherapy used for the treatment of a wide variety of cancers, including non-small cell lung cancer, melanoma and classical Hodgkin lymphoma. It is one of the most sought-after medicines for use as a comparator in clinical trials. Because of this, the manufacturer makes sourcing the product challenging and commands a very high premium for its use in clinical trials compared to the wholesale price of the product in most European markets. Our client, a leading global pharmaceutical company, required considerable volumes of the product for their clients’ trials and came to CSI for a cost-effective sourcing solution.

Solution

CSI identified reliable suppliers that could offer the product in significant volumes with all the relevant documents available and no trial disclosure required, and all at a price significantly lower than that offered to our client by the manufacturer: a 30% reduction when all supporting documentation was required, and 40% when Certificates of Analysis (CoA) were not mandatory.

Result

CSI has been delivering pembrolizumab (sourced at 30–40% lower than the manufacturer’s price) consistently to our pharmaceutical company client for the past couple of years, fulfilling seven purchase orders on time and, in the process, delivering a saving in the region of €1 million.

Case Study

Delivering €1 million Savings for Pembrolizumab

How CSI has saved a leading global pharmaceutical company €1 million by sourcing pembrolizumab from the market at the best possible price

Challenge

To source large quantities of an expensive oncology drug for a pharmaceutical company at a price much lower than that offered by the manufacturer

Solution

CSI leveraged its network of reliable suppliers to present sourcing options to the client that demonstrated a considerable discount

Result

Our client has been supplied with pembrolizumab consistently for the past couple of years, saving €1 million thanks to CSI’s sourcing solutions

Get in touch with a member of our experienced team today to discuss your clinical trial supply requirements

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